Gene-Environment interactions in asthma: what we know today?
نویسندگان
چکیده
Asthma is a complex respiratory disease characterized by episodes of variable airflow obstruction with clinical symptoms such as wheezing, coughing and shortness of breath. The classic definition of asthma as a single disease has begun to wane and the emerging concept is that asthma is an entity or a syndrome consisting of various different phenotypes, each involving different pathogenetic mechanisms1,2. This idea has resulted from the large number of asthmatic phenotypes described and the numerous risk factors and immunological mechanisms that have been identified3-5. Asthma, with its various phenotypes, is a complex disease, resulting from the action of multiple environmental and genetic susceptibility factors. The development of the complex disease or syndrome is a process that depends on the interaction of these factors, in gene-gene, environmentenvironment and gene-environment manners, within a complex biological system6. Through years of research and effort, hundreds of genetic and environmental factors have been shown to be associated with asthma7,8. Despite these efforts, however, only few of these factors have become widely accepted. The two main reasons for this difficulty are the heterogeneity of asthma phenotypes and the inherent complexity of the disease.
منابع مشابه
Gene–Environment Interactions—What Can These Tell Us about the Relationship between Asthma and Allergy?
Asthma is a common condition, which is associated with atopy and allergic conditions including hay fever, eczema, and food allergies. Asthma and atopy are both complex conditions where genetic and environmental factors are implicated in causation. Interactions between genetic and environmental factors, likely via epigenetic mechanisms, are widely thought to be important in determining the risk ...
متن کاملAnalysis of Gene Expression, Signaling Pathways, and Interaction Networks of Some Effective Genes in Patients with Asthma in Microarray Studies Using R Software
Background and purpose: Asthma is a chronic inflammatory disorder of the airways caused by a combination of complex environmental and genetic interactions. There is an incomplete understanding of this mechanism which affect both severity of the disease and how it responds to treatment. Different gene expressions are reported in patients with asthma and healthy controls. Materials and methods:...
متن کاملPerinatal Gene-Gene and Gene-Environment Interactions on IgE Production and Asthma Development
Atopic asthma is a complex disease associated with IgE-mediated immune reactions. Numerous genome-wide studies identified more than 100 genes in 22 chromosomes associated with atopic asthma, and different genetic backgrounds in different environments could modulate susceptibility to atopic asthma. Current knowledge emphasizes the effect of tobacco smoke on the development of childhood asthma. T...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2012